Overview
The pterygopalatine fossa is a cone-shaped fossa on both sides of the skull that serves as a major distribution centre for parasympathetic innervation and vascular supply of deep facial structures. It is located between the pterygoid process and maxillary tuberosity (near the apex of the orbit).

Borders
- Anterior – Posterior wall of the maxillary sinus
- Posterior – Pterygoid process of the sphenoid bone
- Inferior – Palatine bone and palatine canals
- Superior – Inferior orbital fissure of the eye
- Medial – Perpendicular plate of the palatine bone
- Lateral – Pterygomaxillary fissure
Contents
Nerves
- Maxillary branch of trigeminal nerve (CN V2) – Enters from middle cranial fossa via foramen rotundum
- Pterygopalatine ganglion – suspended by the nerve roots from the maxillary nerve
Vessels
- Maxillary artery – the pterygopalatine portion (third part) of the maxillary artery enters via the pterygomaxillary fissure, loops within the fossa and gives rise to terminal branches;
- Infraorbital artery – lacrimal gland and muscles of eye via inferior orbital fissure
- Sphenopalatine artery – nasal cavity via sphenopalatine foramen
- Pharyngeal artery – nasal cavity via pharyngeal canal
- Descending palatine artery – greater and lesser palatine arteries (hard and soft palates) via greater palatine canal
- Posterior superior alveolar artery – to gingiva and teeth via pterygomaxillary fissure
- Artery of pterygoid canal – middle cranial fossa via pterygoid canal.
Communications & Relations
Posteriorly
- Foramen rotundum (posterosuperiorly)
- Communicates with the middle cranial fossa – Meckel’s cave and cavernous sinus
- Transmits the maxillary division of trigeminal nerve
- Pterygoid (Vidian) canal (posteroinferiorly)
- Communicates with the middle cranial fossa and foramen lacerum
- Transmits the vidian nerve, vidian artery and vidian vein
- Palatovaginal (pharyngeal canal) (posteromedially)
- Communicates with the nasopharynx
- Transmits the pharyngeal nerve and pharyngeal branch of the maxillary artery
Anteriorly
- Inferior orbital fissure
- Communicates with the orbit
- Transmits the infraorbital artery
Medially
- Sphenopalatine foramen
- Communicates with the nasal cavity
- Transmits the sphenopalatine artery, nasopalatine nerve and posterior superior nasal nerves
Laterally
- Pterygomaxillary fissure
- A triangular-shaped opening located on the medial aspect of the infratemporal fossa
- Transmits the posterior superior alveolar nerve and terminal branches of the maxillary artery
Inferiorly
- Greater palatine canal (pterygopalatine)
- Communicates with the oral cavity and lesser palatine canals
Relations
Through 8 bony canals or foramina, the fossa communicates with the following structures:
- medially connected to nasal cavity (superior meatus) via sphenopalatine foramen, transmits sphenopalatine artery and vein and nasaopalatine nerve.
- inferiorly the less and greater palatine canals communicate with the oral cavity.
- anterosuperiorly connected to orbital apex via posteromedial aspect of infraorbital fissure.
- laterally continuous with infratemporal fossa via pterygomaxillary fissure (transmits posterior superior alveolar artery and terminal part of maxillary artery).
- posteriorly:
- foramen rotundum – above and lateral to pterygoid canal, connects pterygopalatine fossa with middle cranial fossa, transmits the maxillary nerve.
- pterygoid or vidian canal – lies between roots of medial and lateral pterygoid plates connecting pterygopalatine fossa with with foramen lacerum.
- pharyngeal or palatinovaginal canal – formed by junction of processus vaginalis of sphenoid and sphenoidal process of nasophraynx with the pterygopalatine fossa, transmitting pharyngeal branch of maxillary nerve and artery.
Clinical relevance
- Potential conduit for dissemination of disease process to contiguous structures.
